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3 years ago
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare but severe genetic cardiac arrhythmia disorder. Clinically, CPVT most often presents in childhood with symptoms such as syncope or sudden cardiac death due to polymorphic ventricular tachycardia (VT) or ventricular fibrillation typically triggered by exercise or emotions in the absence of structural heart disease.1
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1 year ago
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3 years ago
Implantable cardioverter defibrillators (ICDs) have been used for over 30 years to prevent sudden cardiac death (SCD). The first indications for ICD placement were secondary prevention; later trials demonstrated a primary prevention benefit of ICD therapy in patients at risk of SCD. ICD therapy prolongs life in both patient populations.1 However, the efficacy of an ICD depends on its ability to…
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3 years ago
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3 years ago
Atrial fibrillation (AF) is the most common cardiac arrhythmia encountered in clinical practice.1 It has been estimated that >3million people in the US and >4.5 million in the EU have paroxysmal or persistent AF.2–4 AF is associated with an approximately fivefold increased risk of stroke,5 threefold risk of heart failure,6 diminished quality of life7 and increased healthcare costs.8,9…
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3 years ago
Sudden cardiac death (SCD) is a major public health concern worldwide, accounting for 50 % of cardiovascular mortality.1 Reduced left ventricular ejection fraction (LVEF) is presently used to identify patients at high risk for primary prevention using implantable cardioverter defibrillator (ICD) therapy, but currently only a minority of patients meeting the criteria for prophylactic ICD receive…
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3 years ago
Despite the clear improvements in clinical outcomes brought about by medical therapy with β-blockers, ACE inhibitors and aldosterone antagonists, as well as by device therapy with cardiac resynchronisation, many patients with chronic heart failure (HF) remain symptomatic despite optimal medical therapy. Symptomatic HF can have devastating consequences for the quality of life of individuals, and…
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3 years ago
Syncope and palpitations are two common clinical presentations, and both pose difficulties in the approach to their management. They are both symptoms of a number of syndromes, and an efficient approach with targeted therapy is challenging. Cardiac arrhythmia specialists, who lack a compact and accessible guide to management, see many patients with these symptoms in consultation. Recognising this…
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3 years ago
Arrhythmogenic cardiomyopathy (ACM) is usually referred to as arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D).1A first historical description was made in 1736, whereas its first modern description dates back to 1982.2 Initially, ACM was thought to be an embryological malformation.3 Yet in recent years it became evident that the pathophysiology of an ongoing genetically…
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3 years ago
Since the 1990s, the publication of several large randomised controlled trials (RCTs) have established the efficacy of implantable cardioverter defibrillator (ICD) therapy in reducing the risk of sudden cardiac death (SCD) in high-risk patients. Collectively these trials have demonstrated a significant all-cause mortality reduction compared with medical therapy alone, for both the primary and…
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