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Author(s):
Demosthenes G Katritsis
Added:
3 years ago
Since its first description by Hays in England in 1906, second-degree atrioventricular (AV) block has been a fascinating clinical entity, mainly due to obscure points regarding its diagnosis that emanate from misconceptions and errors regarding its proper definition.1–3 The practicing clinician should be aware of the following points that may assist a proper diagnosis and, consequently, accurate…
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Author(s):
Mark E Josephson
Added:
3 years ago
In patients with syncope or episodes of palpitations and heart disease, an electrophysiology study (EPS) may be of value by means of potential induction of sustained ventricular tachyarrhythmias.1,2 Programmed ventricular stimulation may be useful in the context of risk stratification of ischaemic patients with left ventricular ejection fraction (LVEF) 30–40 %, and there has been some evidence…
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Author(s):
Demosthenes G Katritsis
Added:
3 years ago
The ideal pacing site in the ventricle(s) of patients with atrioventricular (AV) block has been debated for years. Despite considerable technological advances, the optimal ventricular pacing site to mimic normal human ventricular physiology and attain the best haemodynamic response remains elusive.1
Prolonged ventricular dyssynchrony induced by long-term right ventricular (RV) apical pacing is…
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Author(s):
Dario DiFrancesco
Added:
3 years ago
HCN4 (hyperpolarisation-activated, cyclic nucleotide gated 4) channels, the pore-forming α–subunits of ‘funny’ channels originally described in pacemaker cells of the sinoatrial node (SAN),1 are responsible for the early phase of diastolic depolarisation in these cells and are key determinants of pacemaker generation and control of heart rate.2–5 HCN4 channels are selectively expressed in the SAN…
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Author(s):
Agnieszka Smoczynska
,
Henriëtte DM Beekman
,
Marc A Vos
Added:
3 years ago
The plasticity of the heart enables it to adapt to certain pathological insults and to maintain the cardiac output necessary to satisfy the metabolic requirements of the body.1 Although beneficial at first, this process of ventricular remodelling can have detrimental effects on cardiac function and contribute to arrhythmogenesis.2 Sudden cardiac death due to ventricular tachyarrhythmias accounts…
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Author(s):
Mark Young Lee
,
Srinath Chilakamarri Yeshwant
,
Sreedivya Chava
,
et al
Added:
3 years ago
Aortic stenosis (AS) is the most common valvular heart disease in industrialised countries with a prevalence of about 5 % in the general population aged greater than 75 years. During the past decade, transcatheter aortic valve replacement (TAVR) has emerged as a valuable, minimally invasive treatment option for patients presenting with symptomatic severe AS, who due to their advanced age and…
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Author(s):
Melani Sotiriadou
,
Antonios P Antoniadis
,
Nikolaos Fragakis
,
et al
Added:
2 years ago
Author(s):
Demosthenes G Katritsis
Added:
3 years ago
Although the exact circuit of atrioventricular nodal re-entrant tachycardia (AVNRT) still eludes us, AVNRT is the most common regular arrhythmia in humans, and therefore the most commonly encountered during ablation attempts for regular tachycardias.1–4 Catheter ablation for AVNRT is the current treatment of choice in symptomatic patients. It reduces arrhythmia-related hospitalisations and costs,…
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Author(s):
David Hamon
,
Jane Taleski
,
Marmar Vaseghi
,
et al
Added:
3 years ago
Orthotopic heart transplantation (OHT) is the most effective long-term therapy for end-stage heart disease, with implanted left ventricular assist devices (‘destination therapy’) as an alternative for selected patients. The denervation of the transplanted heart with complete loss of autonomic nervous system modulation, the use of immunosuppressant drugs, as well as the risk of allograft rejection…
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Author(s):
JC Pachon
Added:
3 years ago
Dear Sir,
In December, Dr Stavrakis and Dr Po published the excellent article “Ganglionated Plexi Ablation: Physiology and Clinical Applications” in AER.1 Despite the outstanding quality, unfortunately the article presents a very small fault.
The authors state that autonomic ablation for the treatment of bradyarrhythmias was proposed by Yao. GP ablation for vasovagal syncope was first…
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