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3 years ago
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiomyopathy characterised by progressive replacement of the ventricular myocardium by fibrofatty tissue.1 Patients with the disease are predisposed to ventricular arrhythmias, heart failure and sudden cardiac death.
Pathophysiology
ARVC has a strong genetic basis with most disease variants displaying an autosomal dominant…
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3 years ago
Atrial fibrillation (AF) is the most common arrhythmia experienced in clinical practice, and is responsible for significant morbidity and mortality.1 It affects more than 6 million people in Europe.1 The lifetime risk of developing AF after the age of 40 is approximately 25 %.1 AF is a major public health burden as it is associated with an increased risk of stroke by fivefold, dementia by twofold…
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3 years ago
Ventricular arrhythmias are a therapeutic challenge. They occur frequently in clinical practice, are found in patients with and without structural heart disease, and most importantly, are unpredictable and potentially deadly. Patients with a history of sustained ventricular tachycardia (VT) and VF or those at high risk for such arrhythmias, may require an ICD to prevent sudden cardiac arrest…
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3 years ago
Implantable cardioverter defibrillators (ICDs) have been used for over 30 years to prevent sudden cardiac death (SCD). The first indications for ICD placement were secondary prevention; later trials demonstrated a primary prevention benefit of ICD therapy in patients at risk of SCD. ICD therapy prolongs life in both patient populations.1 However, the efficacy of an ICD depends on its ability to…
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3 years ago
Sudden cardiac death (SCD) is one of the leading causes of death in developed countries. The yearly incidence of SCD is estimated to be 3,000,000 worldwide and between 300,000–450,000 in both the US and Western Europe.1,2 The survival rate for SCD is <1 % worldwide and close to 5 % in the developed world.3 In the past, cardiac arrest was thought to be most commonly due to ventricular…
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3 years ago
Ventricular arrhythmias remain a major contributor to cardiac morbidity and mortality worldwide, despite ongoing research and implementation of novel therapeutic interventions. Modern management of patients with ventricular arrhythmias requires a multidisciplinary team approach, especially in complex presentations with a background of multiple medical comorbidities.1,2 Such teams may include…
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3 years ago
Atrial fibrillation (AF) is the most common cardiac arrhythmia affecting 1.5–2 % of the general population.1 In the current clinical guidelines, catheter ablation is recommended in addition to drug-based antiarrhythmic therapy for patients suffering from symptomatic, drugrefractory AF. However, catheter ablation, if performed at an experienced centre, may also serve as first-line therapy in…
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3 years ago
Premature ventricular complexes (PVCs) are the most common ventricular arrhythmia. Their prognostic significance cannot be interpreted without considering the presence or absence of any associated underlying cardiac condition. In the absence of structural heart disease, PVCs were generally considered to be benign.1,2 In the 1970s and 1980s, it was postulated that frequent PVCs could be a trigger…
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Convergent AF Ablation
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3 years ago
Article
Added:
3 years ago
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare but severe genetic cardiac arrhythmia disorder. Clinically, CPVT most often presents in childhood with symptoms such as syncope or sudden cardiac death due to polymorphic ventricular tachycardia (VT) or ventricular fibrillation typically triggered by exercise or emotions in the absence of structural heart disease.1
Mutations…
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