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Author(s): George Thomas , Jiwon Kim , Bruce B Lerman Added: 3 years ago
CRT is an essential treatment for patients with heart failure and reduced ejection fraction as it can restore left ventricular (LV) electrical and mechanical synchrony. It has been shown to increase quality of life, improve functional status, reduce hospitalisation, improve LV systolic function and reduce mortality in properly selected patients.1,2 While CRT is an effective therapy, approximately… View more

Heart Failure

Electrophysiology & Arrhythmia
Author(s): Geoffrey F Lewis , Michael R Gold Added: 3 years ago
Since the introduction of CRT more than 20 years ago, its role in mild to severe systolic heart failure has become well established. CRT has been shown to decrease mortality, reduce heart failure hospitalisations and improve functional status in patients with NYHA class II–IV heart failure and QRS prolongation, most commonly with LBBB pattern.1 One of the major limitations of CRT implementation… View more

Heart Failure

Electrophysiology & Arrhythmia
Author(s): Demosthenes G Katritsis Added: 3 years ago
Mechanical dyssynchrony, ie nonsynchronous contraction of the wall segments of the left ventricle (intraventricular) or between the left and right ventricles (interventricular), impairs systolic function and ventricular filling, increases wall stress and worsens mitral regurgitation. It is most readily defined by the presence of QRS widening and left bundle branch block (LBBB) configuration on… View more

Standards & Guidelines

Electrophysiology & Arrhythmia
Author(s): Matthew J Dewhurst , Nicholas J Linker Added: 3 years ago

Standards & Guidelines

Heart Failure
Author(s): Khang-Li Looi , Anthony SL Tang , Sharad Agarwal Added: 3 years ago
Heart failure (HF) is a growing and major health burden in western countries. The prevalence of HF is estimated at 1–2 % in the western world, and the incidence approaches 5–10 per 1,000 persons per year.1Cardiac resynchronisation therapy (CRT) has been shown in multiplestudies to improve HF symptoms, quality of life and improve survivals.2–6The two landmark studies, Comparison of Medical Therapy… View more

Heart Failure

Electrophysiology & Arrhythmia
Management of Non-responders to Cardiac Resynchronisation Therapy with MultiPoint Pacing
Author(s): Žarko Calovic Added: 8 years ago

Heart Failure

Electrophysiology & Arrhythmia
Author(s): Haipeng Tang , Shaojie Tang , Weihua Zhou Added: 3 years ago
Cardiac resynchronisation therapy (CRT) is a widely-performed standard treatment for improving cardiac function and quality of life in patients with heart failure.1 After CRT, however, 30–40 % of patients do not experience improvements in left ventricular (LV) function and clinical symptoms.2–3 The key factors for increasing the response rate to CRT are identification of the optimal LV lead… View more

Heart Failure

Electrophysiology & Arrhythmia
Electrical Mapping to Optimise Heart Failure Outcomes Following Cardiac Resynchronisation Therapy
Author(s): David O’Donnell Added: 8 years ago

Heart Failure

Electrophysiology & Arrhythmia
Clinical Evidence Demonstrating the Benefit of MultiPoint Pacing Cardiac Resynchronisation Therapy
Author(s): Axel Kloppe Added: 8 years ago

Heart Failure

Electrophysiology & Arrhythmia
Author(s): Antonio Sorgente , Riccardo Cappato Added: 3 years ago
Cardiac resynchronisation therapy (CRT) is a well-established non-pharmacological treatment option for patients with refractory symptomatic heart failure (HF) already under optimal medical therapy.1 CRT is founded on the principle that interventricular conduction disturbances and especially left bundle branch block (LBBB) are deleterious to cardiac performance and may contribute to the systolic… View more

Heart Failure

Electrophysiology & Arrhythmia