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Author(s): Frédéric Schnell , Nathalie Behar , François Carré Added: 3 years ago
Congenital long QT syndrome (LQTS) is an inherited cardiac ion channelopathy characterised by a variable degree of QT interval prolongation on ECG and an increased susceptibility to life-threatening ventricular arrhythmias (torsades de pointes and ventricular fibrillation) in the absence of morphological cardiac disease. LQTS is estimated to affect one in 2,000 individuals.1 It is usually… View more

Electrophysiology & Arrhythmia

Heterogeneous Populations
Author(s): Luca Sala , Massimiliano Gnecchi , Peter J Schwartz Added: 3 years ago
Long QT Syndrome Long QT syndrome (LQTS) is a potentially severe arrhythmogenic disorder, affecting more than one in 2,000 people worldwide.1 It is characterised by a marked prolongation of the QT interval on the electrocardiogram and major cardiac events, such as syncope, cardiac arrest or sudden death, especially under conditions of physical or emotional stress.2,3 The current diagnostic… View more

Electrophysiology & Arrhythmia
Author(s): Nabil El-Sherif , Gioia Turitto , Mohamed Boutjdir Added: 3 years ago
Since its initial description by Jervell and Lange-Nielsen in 1957,1 congenital long QT syndrome (LQTS) has been the most investigated cardiac ion channelopathy. A prolonged QT interval on the surface ECG is a surrogate measure of prolonged ventricular action potential duration (APD). Congenital as well as acquired alterations in certain cardiac ion channels can affect their currents in such a… View more

Electrophysiology & Arrhythmia
Sex Hormones and Repolarization Dynamics in Women with Long QT Syndrome
Author(s): Ilan Goldenberg Added: 1 year ago
In this video from HRS 2022, Dr Ilan Goldenberg (University of Rochester Medical Center, Rochester, NY, US) joins us to discuss the findings of a recent study which aimed to evaluate the effect of sex hormones during the menstrual cycle on repolarisation dynamics in women with congenital and drug-induced long QT syndrome. Discussion points: 1. Aim, and endpoints 2. Study design 3. Key findings 4… View more

Electrophysiology & Arrhythmia
Warren Jackman
Prof Jackman is the George Lynn Cross Research Professor at theUniversity of Oklahoma Health Sciences Center andSenior Scientific Advisor atthe Heart Rhythm Institute. Prof Jackman is a member of theArrhythmia & Electrophysiology Revieweditorial board. View more
Dr Phillip Cuculich
Dr Phillip Cuculich graduated from Vanderbilt University School of Medicine, Nashville, USA in 2001 and has since trained at Northwestern University, Chicago and the Barnes-Jewish Hospital, Washington University, St Louis, USA where he is currently an Associate Professor of Medicine in the Cardiovascular Division. His clinical interests include arrhythmias, sudden cardiac death, atrial… View more
Author(s): Antonio Zaza , Carlotta Ronchi , Gabriella Malfatto Added: 3 years ago
The incidence of ventricular arrhythmias is often related, within an individual, to the rate of their underlying sinus rhythm (heart rate). The direction of this relationship is generally considered to entail some prognostic significance: whereas ectopic activity suppressed by tachycardia is assumed to be benign, an arrhythmia enhanced by tachycardia is regarded with more concern. Is this… View more

Electrophysiology & Arrhythmia
Sudden Cardiac Death and Arrhythmias
Author(s): Neil T Srinivasan , Richard Schilling Added: 3 years ago
An estimated 180,000–300,000 sudden cardiac deaths (SCD) occur in the US annually.1,2 Worldwide, sudden and unexpected cardiac death is the most common cause of death,2 accounting for 17 million deaths every year with SCD accounting for 25% of these. The accepted definition of SCD is death that occurs within one hour of onset of symptoms in witnessed cases, and within 24 hours of last being seen… View more

Heart Failure

Electrophysiology & Arrhythmia
Author(s): Greg Mellor , Elijah R Behr Added: 3 years ago
Sudden unexplained death syndrome (SUDS)1 is rare in the young but when it occurs it is devastating for family and friends, and affects whole communities. That it can affect fit, athletic individuals and may be related to competitive sports only adds to the sense of incomprehension and injustice felt by wider society. In comparison with the older population, where sudden death is more common and… View more

Heart Failure

Electrophysiology & Arrhythmia
AER Sicouri
Author(s): Serge Sicouri , Charles Antzelevitch Added: 3 years ago
The link between sudden unexplained death in individuals with mental health problems who are administered antipsychotic drugs has been recognised for over a century.1 A clear relationship has emerged over the past 25 years between antipsychotic drugs, prolongation of the QT interval of the ECG, atypical polymorphic tachycardia known as torsade de pointes (TdP) and sudden cardiac death (SCD). A… View more

Electrophysiology & Arrhythmia