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Author(s): Angelo Auricchio Added: 3 years ago
Despite the fact that more than 20 years have passed since the clinical introduction of cardiac resynchronisation therapy (CRT), one of the key questions – do we need an ICD for primary prevention of sudden cardiac death (SCD) in CRT patients? – is still unanswered. Prospective Randomised Controlled Trials Multiple prospective randomised controlled trials have been conducted to establish the… View more
Author(s): Khang-Li Looi , Anthony SL Tang , Sharad Agarwal Added: 3 years ago
Heart failure (HF) is a growing and major health burden in western countries. The prevalence of HF is estimated at 1–2 % in the western world, and the incidence approaches 5–10 per 1,000 persons per year.1Cardiac resynchronisation therapy (CRT) has been shown in multiplestudies to improve HF symptoms, quality of life and improve survivals.2–6The two landmark studies, Comparison of Medical Therapy… View more
Author(s): Peter J Schwartz Added: 3 years ago
Despite the clear improvements in clinical outcomes brought about by medical therapy with β-blockers, ACE inhibitors and aldosterone antagonists, as well as by device therapy with cardiac resynchronisation, many patients with chronic heart failure (HF) remain symptomatic despite optimal medical therapy. Symptomatic HF can have devastating consequences for the quality of life of individuals, and… View more
Author(s): Angela Hall , Andrew RJ Mitchell Added: 3 years ago
AF is the most common clinical arrhythmia, affecting at least 1–2% of the population.1,2 Its prevalence increases with age, with 5% of people aged over 65 years developing AF, climbing to 8% in those aged over 75 years.3 AF is associated with increased morbidity and mortality and has significant public health implications.4 Patients presenting with new onset AF to emergency departments can be… View more
Author(s): Antonio Sorgente , Riccardo Cappato Added: 3 years ago
Cardiac resynchronisation therapy (CRT) is a well-established non-pharmacological treatment option for patients with refractory symptomatic heart failure (HF) already under optimal medical therapy.1 CRT is founded on the principle that interventricular conduction disturbances and especially left bundle branch block (LBBB) are deleterious to cardiac performance and may contribute to the systolic… View more
Author(s): Wei-Yao Lim , Sandeep Prabhu Added: 3 years ago
The number of cardiac implantable electronic devices (CIED) has been increasing year-on-year.1 This, coupled with improvements in life expectancy,2 means that more elderly patients will meet the criteria for a CIED. National and international guidelines set out clear criteria and make recommendations for CIED use based on available evidence.3–6 However, the majority of clinical trials include few… View more
Author(s): David J Callans , Matthew Reynolds , Peter J Zimetbaum Added: 3 years ago
There was a joke years ago that no one understood electrophysiologists, or even wanted to, and that suited us just fine. We were happy to be isolated in our labs working on largely academic problems. Fast forward to now, and the monumental advances in our ability to map and ablate arrhythmias and in new strategies for implantable device therapy have thrust us into the realm of high-volume… View more
Author(s): Deepika Narasimha , Anne B Curtis Added: 3 years ago
Implantable cardiac devices such as implantable cardioverter- defibrillators (ICDs) and cardiac resynchronisation therapy (CRT) devices lead to improved survival and better clinical outcomes in appropriately selected patients with heart failure (HF) with a reduced ejection fraction (EF). Although there are significant sex differences in the aetiology, pathophysiology and clinical course of HF,… View more
Author(s): Niraj Varma , Renato Pietro Ricci , Loredana Morichelli Added: 3 years ago
Monitoring after implant of patients with cardiac implantable electronic devices (CIED) forms a part of both device and patient care, and is the responsibility of the implanting centre. Monitoring is challenged by the increasing number and technical complexity of implanted devices coupled with the increasing clinical complexity of the patient population. Current practice is based on quarterly to… View more
Author(s): Rahul K Mukherjee , Steven E Williams , Steve Niederer , et al Added: 3 years ago
AF is the most common cardiac arrhythmia of clinical significance with an estimated prevalence of >33 million individuals globally.1 AF can be associated with significant symptoms and impaired quality of life of affected patients while also increasing the risk of stroke, heart failure and death.2 AF frequently co-exists with heart failure (HF). Up to half of patients with HF in the Framingham… View more