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Authors’ Reply: His Bundle Pacing: A New Frontier in the Treatment of Heart Failure

… ventricular lead position Dr Zografos points out that randomised comparisons of different right ventricular lead … therefore a degree of inter -ventricular dyssynchrony. The clinical significance of this is not yet known. It is … with preserved LV systolic function means that the trial is designed to prevent, rather than treat, …

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Article

Electrophysiology’s Identity Crisis: What our Clinical Trials Do and Do Not Say About Us

… Article Electrophysiology's Identity Crisis: What our Clinical Trials Do and Do Not Say About Us David J Callans , … it has not always been this way, the impact of large, randomised clinical trials in electrophysiology is limited, … to accomplish this goal. Keywords Randomised clinical trial , catheter ablation , ventricular tachycardia , AF , …

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Prophylactic Catheter Ablation for Ventricular Tachycardia: Are We There Yet?

… implantable cardioverter-defibrillator shocks. Three major randomised, controlled trials have been published … techniques have been made. A number of large, multicentre, clinical trials are seeking to address some of the unanswered … has proved notoriously difficult ( Table 1 ). The SMASH-VT trial, despite having a 4-year enrolment period across three …

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Upstream Treatment of Atrial Fibrillation with n-3 Polyunsaturated Fatty Acids: Myth or Reality?

… a possible use of n-3 PUFA in AF prevention. Several randomised clinical trials have been designed to evaluate the efficacy … in the prevention of AF was assessed in a randomised trial of 663 outpatients carried out in the US. Patients had …

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Controversy Surrounding ROCKET-AF: A Call for Transparency, But Should We Be Changing Practice?

… Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation), published in the New England … systemic embolism in patients with AF. This double-blinded randomised trial, which included 14,264 patients across 45 … of transparency of the specifics of devices used in large clinical trials. In response, the authors from ROCKET-AF …

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Developments in Cardiac Resynchronisation Therapy

… R Gold has received consulting fees and has performed clinical trials with Boston Scientific, Medtronic and St … populations has been demonstrated in multiple large, randomised clinical trials (RCTs). The first multi-centre, randomised trial to demonstrate clinical benefits of CRT was the …

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Catheter Ablation for Atrial Fibrillation in Systolic Heart Failure Patients : Stone by Stone, a CASTLE

… are performed in patients with coexistent HF. Initial randomised data on outcomes are encouraging. Apart from sinus … a treatment option for AF and has been widely utilised in clinical practice, which has been reflected in recent … in Patients with Congestive Heart Failure (PABA CHF) trial investigators evaluated CA versus AVNA plus …

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Improving Cardiac Resynchronisation Therapy

… in Systolic left vEntricular dysfunction (REVERSE) trial also showed benefit in patients with RBBB receiving … CRT response. QRS duration is a criterion for every large clinical trial showing benefit in CRT. Trials randomising … activation for placement of the LV lead. Patients randomised to the targeted LV lead placement group had lower …

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Treatment of Atrial Fibrillation in Patients with Coexisting Heart Failure and Reduced Ejection Fraction: Time to Revisit the Management Guidelines?

… traditionally limited to the use of antiarrhythmic drugs. Clinical trials assessing superiority of pharmacological … on Dofetilide in Congestive Heart Failure (DIAMOND-CHF) trial, 17 1,518 patients were randomised to receive either dofetilide (n=762) or placebo …

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Article

The Cryoballoon vs Irrigated Radiofrequency Catheter Ablation (CIRCA-DOSE) Study Results in Context

… Exposure Duration (CIRCA-DOSE) study was a multicentre, randomised, single-blinded trial that compared contact-force radiofrequency ablation and … 10,11 Study Design The CIRCA-DOSE study was a pragmatic clinical trial, designed to evaluate two separate clinically …

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