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Adenosine Test in Syncope of Unknown Origin
Author(s): Melani Sotiriadou , Antonios P Antoniadis , Nikolaos Fragakis , et al Added: 2 years ago

Electrophysiology & Arrhythmia
Unmasking Adenosine: The Purinergic Signalling Molecule Critical to Arrhythmia Pathophysiology and Management
Author(s): Gareth DK Matthews , Andrew Grace Added: 3 years ago
The use of adenosine in cardiology is ubiquitous. From arrhythmia to coronary intervention to cardiac imaging, adenosine is an essential part of everyday practice because of its widespread effects on electrophysiology and the coronary vasculature. Electrophysiologists will be most familiar with adenosine for its use in terminating supraventricular tachycardias (SVTs) that are dependent on the… View more

Heart Failure

Electrophysiology & Arrhythmia
Drug-induced AF: Arrhythmogenic Mechanisms and Management Strategies
Author(s): Bingxun Li , Mingjie Lin , Lin Wu Added: 2 weeks ago

Electrophysiology & Arrhythmia
Author(s): Jean-Baptiste Gourraud , Jason G Andrade , Laurent Macle , et al Added: 3 years ago
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia observed in clinical practice, occurring in approximately 2 % of the general population.1–3 A progressive increase in both the prevalence and incidence of AF has been demonstrated in recent years, defining AF as a major economic and public health issue.1 The identification of sites of AF initiation and/or maintenance within… View more

Electrophysiology & Arrhythmia

Prevention & Chronic Conditions
Author(s): Moinuddin Choudhury , Mark R Boyett , Gwilym M Morris Added: 3 years ago
The sinoatrial or sinus node (SAN) is the heart’s natural pacemaker. Located in the superior right atrium, it automatically produces cyclical electrical activity to initiate each heartbeat in normal sinus rhythm. SAN dysfunction (SND) in humans, also known as ‘sick sinus syndrome’, can manifest as pathological bradycardia and asystolic pauses. As a result, SND can lead to symptoms of reduced… View more

Electrophysiology & Arrhythmia
Author(s): David Hamon , Jane Taleski , Marmar Vaseghi , et al Added: 3 years ago
Orthotopic heart transplantation (OHT) is the most effective long-term therapy for end-stage heart disease, with implanted left ventricular assist devices (‘destination therapy’) as an alternative for selected patients. The denervation of the transplanted heart with complete loss of autonomic nervous system modulation, the use of immunosuppressant drugs, as well as the risk of allograft rejection… View more

Vascular Disease and Surgery

Electrophysiology & Arrhythmia
Author(s): Ethan R Ellis , Mark E Josephson Added: 3 years ago
Cardiomyopathies are heterogeneous heart muscle disorders with a wide range of aetiologies and clinical manifestations. They are often defined by their causes (i.e. hypertension, prior myocardial infarction, valvular heart disease), although current major society definitions describe cardiomyopathy as the presence of abnormal myocardial structure and/or function in the absence of underlying… View more

Heart Failure

Electrophysiology & Arrhythmia
At the Atrioventricular Crossroads: Dual Pathway Electrophysiology
Author(s): Sharon A George , N Rokhaya Faye , Alejandro Murillo-Berlioz , et al Added: 3 years ago
More than 100years have passed since the atrioventricular node (AVN) was first discovered by Sunao Tawara1 and described as a “Knoten” of tissue located at the proximal end of the Bundle of His (BoH).2 Despite the numerous advances in knowledge regarding the structure and function of the AVN, there are still several controversies that need to be addressed in both clinical and scientific settings… View more

Electrophysiology & Arrhythmia
Author(s): Zhao Liu , J Kevin Donahue Added: 3 years ago
In the United States, atrial fibrillation (AF) is the most common sustained cardiac arrhythmia affecting approximately six million patients and contributing to a greatly increased risk of stroke, heart failure (HF) and overall morbidity and mortality.1,2 The prevalence of AF is increasing as the average age of the population increases.3,4 Currently available therapies for AF are suboptimal… View more

Electrophysiology & Arrhythmia

Prevention & Chronic Conditions
Author(s): Mark E Josephson Added: 3 years ago
In patients with syncope or episodes of palpitations and heart disease, an electrophysiology study (EPS) may be of value by means of potential induction of sustained ventricular tachyarrhythmias.1,2 Programmed ventricular stimulation may be useful in the context of risk stratification of ischaemic patients with left ventricular ejection fraction (LVEF) 30–40 %, and there has been some evidence… View more

Electrophysiology & Arrhythmia