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Author(s): Simon Ermakov , Melvin Scheinman Added: 3 years ago
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiomyopathy characterised by progressive replacement of the ventricular myocardium by fibrofatty tissue.1 Patients with the disease are predisposed to ventricular arrhythmias, heart failure and sudden cardiac death. Pathophysiology ARVC has a strong genetic basis with most disease variants displaying an autosomal dominant… View more

Standards & Guidelines

Heart Failure
Ivabradine and AF: Coincidence, Correlation or a New Treatment?
Author(s): Mahmoud Abdelnabi , Ashraf Ahmed , Abdallah Almaghraby , et al Added: 3 years ago
Ivabradine is a pure heart rate-lowering agent best characterised by its negative chronotropic effect on the sinoatrial node.1 Its unique mechanism selectively blocks the pacemaker funny (If) channels, which are responsible for spontaneous depolarisation in the sinoatrial node that regulates heart rate during sinus rhythm (Figure 1).2 Since 1980, it has been well established that controlling the… View more

Heart Failure

Prevention & Chronic Conditions
Carlos Morillo
Prof Carlos Morillo is a cardiac electrophysiologist, currently serving in the Chief Division of Cardiology at theLibin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada. Prof Morillo has extensively researched Chagas disease since 1990, and was involved in the initial studies related to autonomic control in the different stages of the disease and the use of beta… View more
Author(s): Farhan Shahid , Gregory YH Lip Added: 3 years ago
Atrial fibrillation (AF) and heart failure (HF) are global epidemics that began more than a century ago, and their association with an ageing general population has brought about an increase in cardiovascular morbidity and rising healthcare costs.1,2 More than 50 % of patients with permanent AF have a concurrent diagnosis of HF and this proportion is expected to rise.3 It is well established that… View more

Heart Failure

Electrophysiology & Arrhythmia
Sudden Cardiac Death and Arrhythmias
Author(s): Neil T Srinivasan , Richard Schilling Added: 3 years ago
An estimated 180,000–300,000 sudden cardiac deaths (SCD) occur in the US annually.1,2 Worldwide, sudden and unexpected cardiac death is the most common cause of death,2 accounting for 17 million deaths every year with SCD accounting for 25% of these. The accepted definition of SCD is death that occurs within one hour of onset of symptoms in witnessed cases, and within 24 hours of last being seen… View more

Heart Failure

Electrophysiology & Arrhythmia
Author(s): Jeffrey J Hsu , Ali Nsair , Jamil A Aboulhosn , et al Added: 3 years ago
Monomorphic ventricular arrhythmias (MMVA) are not uncommon in athletes,1,2 yet their presence appropriately raises concern among practitioners for possible increased risk of sudden cardiac death (SCD) during sports activity and competition. While all MMVA detected in athletes warrant further evaluation,1 a majority of MMVA in this population are likely to be benign. In some instances of so… View more

Heart Failure

Electrophysiology & Arrhythmia
William T Abraham
Research Area(s) / Expertise:

Heart Failure

 Job title: Professor of Internal Medicine and Chief of the Division of Cardiovascular Medicine
Prof Abraham is a College of Medicine Distinguished Professor. He has been recognized as one of the “Best Doctors in America” for 18 consecutive years.His research has led to the approval/adoption of new heart failure therapies, including beta-blockers, natriuretic peptides, cardiac resynchronization therapy, ultrafiltration, implantable hemodynamic monitoring, transvenous phrenic nerve… View more
Author(s): Frédéric Schnell , Nathalie Behar , François Carré Added: 3 years ago
Congenital long QT syndrome (LQTS) is an inherited cardiac ion channelopathy characterised by a variable degree of QT interval prolongation on ECG and an increased susceptibility to life-threatening ventricular arrhythmias (torsades de pointes and ventricular fibrillation) in the absence of morphological cardiac disease. LQTS is estimated to affect one in 2,000 individuals.1 It is usually… View more

Electrophysiology & Arrhythmia

Heterogeneous Populations
Team Management of the Ventricular Tachycardia Patient
Author(s): Pok Tin Tang , Duc H Do , Anthony C Li , et al Added: 3 years ago
Ventricular arrhythmias remain a major contributor to cardiac morbidity and mortality worldwide, despite ongoing research and implementation of novel therapeutic interventions. Modern management of patients with ventricular arrhythmias requires a multidisciplinary team approach, especially in complex presentations with a background of multiple medical comorbidities.1,2 Such teams may include… View more

Electrophysiology & Arrhythmia
Ventricular Arrhythmia after Acute MI
Author(s): Justine Bhar-Amato , William Davies , Sharad Agarwal Added: 3 years ago
Ventricular tachyarrhythmias (VAs) most commonly occur early in ischaemia, and patients presenting with an acute MI and ventricular arrhythmias are a group that has a significantly increased risk of mortality.1,2 Thrombolysis primary percutaneous coronary intervention (PCI) and use of beta-blockers, while resulting in the modification of the natural history of an infarct, have also reduced the… View more

Electrophysiology & Arrhythmia

MI/ACS