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Author(s): Dario DiFrancesco Added: 3 years ago
HCN4 (hyperpolarisation-activated, cyclic nucleotide gated 4) channels, the pore-forming α–subunits of ‘funny’ channels originally described in pacemaker cells of the sinoatrial node (SAN),1 are responsible for the early phase of diastolic depolarisation in these cells and are key determinants of pacemaker generation and control of heart rate.2–5 HCN4 channels are selectively expressed in the SAN… View more

Electrophysiology & Arrhythmia
Septal and Conduction System Pacing
Author(s): Demosthenes G Katritsis , Hugh Calkins Added: 6 months ago

Electrophysiology & Arrhythmia
Author(s): Demosthenes G Katritsis Added: 3 years ago
The ideal pacing site in the ventricle(s) of patients with atrioventricular (AV) block has been debated for years. Despite considerable technological advances, the optimal ventricular pacing site to mimic normal human ventricular physiology and attain the best haemodynamic response remains elusive.1 Prolonged ventricular dyssynchrony induced by long-term right ventricular (RV) apical pacing is… View more

Electrophysiology & Arrhythmia
Author(s): Katrina Mountfort , Reinoud Knops , Johannes Sperzel , et al Added: 3 years ago
Based on Presentations at Nanostim Sponsored Symposium Held at the European Society of Cardiology Congress 2013, Amsterdam, The Netherlands, 2 September 2013 In 1958, the world’s first patient was implanted with a pacemaker. It brought numerous benefits, the most important of which was increased survival. Since then, pacemaker technology has evolved with the development of improved device… View more

Vascular Disease and Surgery

Electrophysiology & Arrhythmia
HRS 2021: The Geisinger-Rush Conduction System Pacing Registry
Author(s): Parikshit S Sharma Added: 2 years ago
In this video interview, Dr Parikshit Sharma (Rush University Medical Center, Chicago, IL, US) discusses the clinical outcomes from the Geisinger-Rush Conduction System Pacing Registry, presented at ESC's Heart Rhythm Society 2021. This was a non-randomized, observational cohort registry, which aimed to compare the results of left bundle branch area pacing compared to right ventricular pacing in… View more

Electrophysiology & Arrhythmia
ESC 23: The DANPACE II Trial
Author(s): Mads Brix Kronborg Added: 7 months ago
ESC 2023 — Dr Mads Brix Kronborg (Aarhus University Hospital, DE) joins us to discuss the findings from the DANPACE II Trial (NCT00236158). DANPACE II (The DANPACE Investigator Group) trial aimed to compare patients who were randomised in a 1:1 ratio to either a base rate of 60 beats per minute and rate-adaptive DDD (DDDR-60 Group) or a base rate of 40bpm and non-rate adaptive DDD (DDD-40… View more

Electrophysiology & Arrhythmia
Cardiac Resynchronisation with Conduction System Pacing
Author(s): Fatima M Ezzeddine , Isaac G Leon , Yong-Mei Cha Added: 8 months ago

Electrophysiology & Arrhythmia
Left Bundle Branch Pacing: A Perfect Compromise?
Author(s): Alexandre Raymond-Paquin , Santosh K Padala , Kenneth A Ellenbogen Added: 2 years ago

Electrophysiology & Arrhythmia
Pacing and Defibrillators in Complex Congenital Heart Disease
Author(s): Henry Chubb , Mark O’Neill , Eric Rosenthal Added: 3 years ago
Device therapy is increasingly employed in the management of complex congenital heart disease (CHD). Bradycardias, most often related to sinus nodal dysfunction (SND) or atrioventricular nodal (AVN) block, may necessitate the implantation of pacing devices, while malignant arrhythmias may be treated by appropriate use of implantable cardioverter defibrillators (ICDs). However, there is a complex… View more

Standards & Guidelines

Heart Failure
New ways to detect and prevent atrial fibrillation in ICD patients
Author(s): Mathias Meine , Mathias Busch , Martin Martinek Start date: Dec 11, 2018

Electrophysiology & Arrhythmia