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Author(s):
Mohamed Abbas
,
Chris Miles
,
Elijah R Behr
Added:
1 year ago
Author(s):
Krystien VV Lieve
,
Arthur A Wilde
,
Christian van der Werf
Added:
3 years ago
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare but severe genetic cardiac arrhythmia disorder. Clinically, CPVT most often presents in childhood with symptoms such as syncope or sudden cardiac death due to polymorphic ventricular tachycardia (VT) or ventricular fibrillation typically triggered by exercise or emotions in the absence of structural heart disease.1
Mutations…
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Author(s):
Giulio Conte
,
Ulrich Schotten
,
Angelo Auricchio
Added:
3 years ago
The Risk of Atrial Arrhythmias in Inherited Primary Arrhythmia Syndromes
The inherited primary arrhythmia syndromes (IPAS) are a heterogeneous group of diseases caused by mutations in genes encoding for cardiac ion channels. People affected by one of these inherited diseases have no overt structural cardiac abnormalities but are at higher risk of sudden cardiac death due to the occurrence of…
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Author(s):
Neil T Srinivasan
,
Richard Schilling
Added:
3 years ago
An estimated 180,000–300,000 sudden cardiac deaths (SCD) occur in the US annually.1,2 Worldwide, sudden and unexpected cardiac death is the most common cause of death,2 accounting for 17 million deaths every year with SCD accounting for 25% of these. The accepted definition of SCD is death that occurs within one hour of onset of symptoms in witnessed cases, and within 24 hours of last being seen…
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Author(s):
A John Camm
,
Bernard J Gersh
,
Demosthenes G Katritsis
Added:
3 years ago
Inherited arrhythmias comprise a group of disorders with inherited susceptibility to arrhythmias and conduction disturbances due to mutations in genes mainly encoding the Na+, and K+ channels, and other arrhythmogenic mechanisms such as those linked to Ca++ transport (Table 1).1 The majority of heritable cardiomyopathies and channelopathies are associated with disease-susceptibility genes…
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Author(s):
Gonca Suna
,
Greg J Mellor
Added:
4 months ago
Author(s):
Penelope A Boyden
,
Wen Dun
,
Bruno D Stuyvers
Added:
3 years ago
Abnormalities in electrical rhythm were studied by Einthoven at the start of the 20th century. In the 1940s, studies by Bozler et al.1 described contractile signals that appeared to be ‘triggered’ heart beats. Today we use the term delayed afterdepolarisations (DADs) to refer to oscillations in voltage that follow a driven action potential.
In the mid-1970s, progress was made when Lederer and…
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Author(s):
Moinuddin Choudhury
,
Mark R Boyett
,
Gwilym M Morris
Added:
3 years ago
The sinoatrial or sinus node (SAN) is the heart’s natural pacemaker. Located in the superior right atrium, it automatically produces cyclical electrical activity to initiate each heartbeat in normal sinus rhythm. SAN dysfunction (SND) in humans, also known as ‘sick sinus syndrome’, can manifest as pathological bradycardia and asystolic pauses. As a result, SND can lead to symptoms of reduced…
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Author(s):
Greg Mellor
,
Elijah R Behr
Added:
3 years ago
Sudden unexplained death syndrome (SUDS)1 is rare in the young but when it occurs it is devastating for family and friends, and affects whole communities. That it can affect fit, athletic individuals and may be related to competitive sports only adds to the sense of incomprehension and injustice felt by wider society. In comparison with the older population, where sudden death is more common and…
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Author(s):
Saad Fyyaz
,
Michael Papadakis
Added:
1 year ago