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Author(s):
Sanjiv M Narayan
,
David E Krummen
Added:
3 years ago
Atrial fibrillation (AF) is the most prevalent arrhythmia in the world and a leading cause of hospitalisation and death.1 Current therapy for AF remains suboptimal, in large part because its mechanisms are uncertain. However, recent advances in our understanding of human AF, from meticulous mapping in patients and insights from animal models, are providing new therapeutic options for patients.
…
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Author(s):
Amir A Schricker
,
Junaid AB Zaman
,
Sanjiv M Narayan
Added:
3 years ago
Catheter ablation is more effective than pharmacological therapy for the secondary prevention of patients with paroxysmal1,2 and persistent3,4 atrial fibrillation (AF) and has an emerging role in the primary prevention of paroxysmal AF.5,6 Nevertheless, in randomised clinical trials (RCTs) its success in treating patients with paroxysmal AF is 40–60% for a single procedure and 70% for multiple…
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Author(s):
Junaid AB Zaman
,
Andrew Grace
,
Sanjiv M Narayan
Added:
1 year ago
Author(s):
Karl-Heinz Kuck
,
Andreas Metzner
Added:
3 years ago
Catheter-based ablation of atrial fibrillation (AF) is an established treatment option for symptomatic patients who are refractory to drug-based treatment, as implemented in the latest guidelines for the management of AF.1 The accepted and recommended cornerstone of all ablation strategies for AF is electrical isolation of the pulmonary veins (PV).2 However, in addition to PV isolation (PVI),…
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Author(s):
Rakesh Latchamsetty
,
Fred Morady
Added:
3 years ago
Catheter ablation of AF has shown steady growth over the past two decades with a nearly 15 % annual increase in the US.1 This growth can be attributed in large part to four factors: an increase in operators and institutions performing the procedure;2 a steady rise in AF prevalence, which is predicted to reach 12 million in the US by 2030;3 a larger spectrum of AF patients with more complex atrial…
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Drivers of Atrial Fibrillation
Author(s):
Ian Mann
,
Belinda Sandler
,
Nick WF Linton
,
et al
Added:
3 years ago
Article
Author(s):
Tina Baykaner
,
Junaid AB Zaman
,
Paul J Wang
,
et al
Added:
3 years ago
Treatment of atrial fibrillation (AF) classically focuses on eliminating triggers near and from the pulmonary veins, which may initiate AF. However, the 1–2 year success rate of pulmonary vein isolation (PVI) remains 40–50% for persistent AF1,2 and 50–65% for paroxysmal AF,3–5 while supplementary linear lesions or extensive ablation at electrogram-targets have had disappointing results and may…
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Author(s):
Jonathan W Waks
,
Mark E Josephson
Added:
3 years ago
Atrial fibrillation (AF), the most common sustained arrhythmia, is a leading cause of stroke, and is associated with significant morbidity and mortality worldwide. Despite its frequency, clinical importance, and advances in technology and our knowledge of the molecular, ionic and physiological fundamentals of cardiac electrophysiology, our limited understanding of the mechanisms that initiate and…
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Author(s):
Caroline H Roney
,
Andrew L Wit
,
Nicholas S Peters
Added:
3 years ago
Determining optimal treatment strategies for complex arrhythmogenesis in AF is confounded by the lack of consensus on the mechanisms causing AF. Fundamental to defining arrhythmogenic mechanisms of AF are the distinctions and interplay between functional features (determined by the electrophysiology of a cell) and structural features (determined by whether a structural or anatomical feature is…
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