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Author(s): Nabil El-Sherif , Gioia Turitto , Mohamed Boutjdir Added: 3 years ago
Since its initial description by Jervell and Lange-Nielsen in 1957,1 congenital long QT syndrome (LQTS) has been the most investigated cardiac ion channelopathy. A prolonged QT interval on the surface ECG is a surrogate measure of prolonged ventricular action potential duration (APD). Congenital as well as acquired alterations in certain cardiac ion channels can affect their currents in such a… View more

Electrophysiology & Arrhythmia
Avoiding Haemodynamic Instability in Ventricular Tachycardia Ablation
Author(s): Benjamin L Freedman , Timothy R Maher , Madison Tracey , et al Added: 10 months ago

Electrophysiology & Arrhythmia
Author(s): Brenton S Bauer , Anthony C Li , Jason S Bradfield Added: 3 years ago
Ventricular arrhythmias (VA) are commonly associated with structural heart disease and have substantial impact on patient outcomes and health system costs. Within the realm of cardiomyopathy (CM), there has been substantial progress with respect to ischaemic CM (ICM) in the understanding of infarct related scar biology and scar-mediated ventricular tachycardia (VT). This has led to interventions… View more

Heart Failure
Author(s): William J Hucker , Jagmeet P Singh , Kimberly Parks , et al Added: 3 years ago
The interplay between the central nervous system and cardiac electrophysiology is fundamental, and becomes obvious each time one’s pulse quickens in response to stress. Normally, cardiac neurohormonal regulation is accomplished through the balanced effects of sympathetic and parasympathetic autonomic stimulation, along with the hormonal regulation of the renin-angiotensinaldosterone system (RAAS)… View more

Imaging & Diagnostics

Electrophysiology & Arrhythmia
Cardioneuroablation for Vasovagal Syncope
Author(s): Le Li , Sunny Po , Yan Yao Added: 10 months ago

Electrophysiology & Arrhythmia

Prevention & Chronic Conditions
Author(s): Ashok J Shah , Meleze Hocini , Patrizio Pascale , et al Added: 3 years ago
The structural and/or functional abnormality of the cardiac electrovascular system is the most common cause of world mortality accounting for 29.0 % of deaths, followed by infectious diseases (16.2 %) and cancers (12.6 %) (WHO 2008 report). 1 Abnormalities in the cardiac electrical system (arrhythmias and sudden death) and/or mechanical function (heart failure) constitute one of the major causes… View more

Imaging & Diagnostics

Heart Failure
Author(s): Tina Baykaner , Junaid Zaman , Paul J Wang , et al Added: 3 years ago
Treatment of atrial fibrillation (AF) classically focuses on eliminating triggers near and from the pulmonary veins, which may initiate AF. However, the 1–2 year success rate of pulmonary vein isolation (PVI) remains 40–50% for persistent AF1,2 and 50–65% for paroxysmal AF,3–5 while supplementary linear lesions or extensive ablation at electrogram-targets have had disappointing results and may… View more

Electrophysiology & Arrhythmia
Author(s): Pascal Vranckx , Marco Valgimigli , Hein Heidbuchel Added: 3 years ago
Anticoagulation with vitamin K antagonists (VKAs) has been used for the long-term treatment and prevention of thromboembolic diseases and for stroke prevention in atrial fibrillation (AF) for the past half century. Until the last decade, VKAs were the only oral anticoagulant (OAC) agents available, and warfarin remains the most commonly prescribed OAC worldwide.1 Direct oral anticoagulants (DOACs… View more

Anticoagulation
Author(s): Luca Sala , Massimiliano Gnecchi , Peter J Schwartz Added: 3 years ago
Long QT Syndrome Long QT syndrome (LQTS) is a potentially severe arrhythmogenic disorder, affecting more than one in 2,000 people worldwide.1 It is characterised by a marked prolongation of the QT interval on the electrocardiogram and major cardiac events, such as syncope, cardiac arrest or sudden death, especially under conditions of physical or emotional stress.2,3 The current diagnostic… View more

Electrophysiology & Arrhythmia
Author(s): Cristina E Molina , Jordi Heijman , Dobromir Dobrev Added: 3 years ago
Optimal cardiac function depends on appropriate rate and force of contraction, with specific cardiac regions having developed particular beat-to-beat properties depending on their individual functions. For example, isovolumetric contraction time is shorter in the right ventricle (RV) than in the left ventricle (LV). At the cellular level, cardiac function is regulated by regional cardiomyocyte… View more

Electrophysiology & Arrhythmia