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Author(s):
C Fielder Camm
,
A John Camm
Added:
3 years ago
Hypertrophic cardiomyopathy (HCM) is a common genetic cardiac disorder, with an autosomal dominant mechanism of inheritance.1,2 It has a prevalence of 1 in 500 within the general population, and is a known cause of sudden cardiac death.2,3 Recognised autosomal dominant mutations within sarcomere proteins are found in 55 % of adolescents with sporadic HCM.4 Characteristic echocardiographic…
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Author(s):
Rahul K Mukherjee
,
Steven E Williams
,
Steve Niederer
,
et al
Added:
3 years ago
AF is the most common cardiac arrhythmia of clinical significance with an estimated prevalence of >33 million individuals globally.1 AF can be associated with significant symptoms and impaired quality of life of affected patients while also increasing the risk of stroke, heart failure and death.2 AF frequently co-exists with heart failure (HF). Up to half of patients with HF in the Framingham…
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Author(s):
Mouhannad M Sadek
,
Robert D Schaller
,
Gregory E Supple
,
et al
Added:
3 years ago
Scar-related reentrant ventricular tachycardia (VT) may be present in a variety of structural heart disease (SHD) phenotypes. In this setting, VT circuits are comprised of viable myocytes separated by fibrosis, allowing for the slow conduction needed to facilitate reentry.1,2 Aetiologies of fibrosis include ischaemic heart disease (IHD), inflammatory conditions, infiltrative cardiomyopathy,…
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Author(s):
Philippe Charron
,
Eloisa Arbustini
,
Gisèle Bonne
Added:
3 years ago
Most mutations of the LMNA gene affect the heart, causing a dilated cardiomyopathy, ususally with conduction defect and ventricular arrhythmia, with or without skeletal muscle involvement. Although a relatively rare disease, cardiologists should be aware of laminopathies (diseases caused by LMNA gene mutations) because of the particularly aggressive course compared with most other…
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Rhythm Control in AF-CHF
Author(s):
William Eysenck
,
Magdi Saba
Added:
3 years ago
Article
Author(s):
David J Sprenkeler
,
Marc A Vos
Added:
3 years ago
The concept of post-extrasystolic potentiation (PESP), which describes the phenomenon of increased contractility of the beat following an extrasystole, has intrigued physiologists and clinicians for more than 120 years. Since its first description in 1885 by Oskar Langendorff,1 PESP has become a widely debated concept, not only for its fundamental basis but also because of the potential…
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Author(s):
Saagar Mahida
Added:
3 years ago
Atrial fibrillation (AF) is a highly prevalent arrhythmia that represents an important burden on healthcare systems. The presence of AF is associated with an increased risk of conditions such stroke, heart failure and dementia. Further, AF is associated with increased mortality. Over the past half century, significant advances have been made in understanding the pathobiology of AF. Important…
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Mapping AF Structural Substrates
Author(s):
Ahmed M Al-Kaisey
,
Ramanathan Parameswaran
,
Jonathan M Kalman
Added:
3 years ago
Article
Author(s):
Nisha Gilotra
,
David Okada
,
Apurva Sharma
,
et al
Added:
3 years ago
Sarcoidosis is an inflammatory granulomatous disease that can affect any organ. Systemic sarcoidosis is known to affect young adults, with a second peak in women >50 years of age, as demonstrated in Scandinavian and Japanese studies.1–4 In the US, the lifetime risk of sarcoidosis is 2.4% for black people and 0.85% for white people.1 The incidence of cardiac involvement has been increasingly…
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Author(s):
Mohamed Abbas
,
Chris Miles
,
Elijah R Behr
Added:
1 year ago