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Author(s):
Konstantinos D Rizas
,
Wolfgang Hamm
,
Stefan Kääb
,
et al
Added:
3 years ago
Experimental and clinical studies have demonstrated that enhanced sympathetic autonomic nervous system (SANS) activity can destabilise myocardial repolarisation,1–4 increasing vulnerability to developing fatal cardiac arrhythmias.5–8 Accordingly, assessment of SANS activity has always been a major goal for cardiac risk stratification methods. Various non-invasive methods including assessment of…
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Author(s):
Shohreh Honarbakhsh
,
Rui Providencia
,
Pier D Lambiase
Added:
3 years ago
Brugada syndrome (BrS) remains one of the most common inherited channelopathies associated with an increased risk of sudden cardiac death (SCD), with a worldwide prevalence of approximately 0.05%.1–3 It is accepted that appropriate utilisation of the ICD in high-risk patients with aborted SCD and haemodynamically compromising arrhythmias is life-saving. However, there remains a lack of consensus…
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Author(s):
Krystien VV Lieve
,
Arthur A Wilde
,
Christian van der Werf
Added:
3 years ago
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare but severe genetic cardiac arrhythmia disorder. Clinically, CPVT most often presents in childhood with symptoms such as syncope or sudden cardiac death due to polymorphic ventricular tachycardia (VT) or ventricular fibrillation typically triggered by exercise or emotions in the absence of structural heart disease.1
Mutations…
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Author(s):
Demosthenes G Katritsis
,
Bernard J Gersh
,
A John Camm
Added:
3 years ago
Sudden cardiac death (SCD) is usually defined as death due to cardiac causes occurring within 1 hour of the onset of symptoms. Unexplained sudden death occurring in an individual older than 1 year of age is known as 'sudden unexplained death syndrome'. Unexplained sudden death occurring in an individual younger than 1 year of age is known as 'sudden unexplained death in infancy'. SCD with…
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Author(s):
Boris Rudic
,
Rainer Schimpf
,
Martin Borggrefe
Added:
3 years ago
Short QT syndrome (SQTS) is a rare, inheritable channelopathy of the heart characterised by abnormally short QT intervals on the electrocardiogram (ECG) and an increased propensity to develop atrial and ventricular tachyarrhythmias in the absence of structural heart disease.1,2 SQTS was first described as a new clinical entity by Gussak et al. in 2000.1 Until then shortening of the QT interval…
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Long QT Syndrome Modelling
Author(s):
Luca Sala
,
Massimiliano Gnecchi
,
Peter J Schwartz
Added:
3 years ago
Article
Author(s):
Nikhil Singh
,
Kegan James Moneghetti
,
Jeffrey Wilcox Christle
,
et al
Added:
3 years ago
Estimation of Prognosis Using HRV
The association of heart rate variability (HRV) and prognosis, both for all-cause and cardiovascular (CV) mortality, has been studied using ECG at rest, with exercise and in the ambulatory setting. A meta-analysis by Hillebrand and colleagues found that, using both resting and ambulatory ECG monitoring, lower HRV is associated with a 32–45% increased risk of…
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Author(s):
A John Camm
,
Bernard J Gersh
,
Demosthenes G Katritsis
Added:
3 years ago
Inherited arrhythmias comprise a group of disorders with inherited susceptibility to arrhythmias and conduction disturbances due to mutations in genes mainly encoding the Na+, and K+ channels, and other arrhythmogenic mechanisms such as those linked to Ca++ transport (Table 1).1 The majority of heritable cardiomyopathies and channelopathies are associated with disease-susceptibility genes…
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Author(s):
Giulio Conte
,
Ulrich Schotten
,
Angelo Auricchio
Added:
3 years ago
The Risk of Atrial Arrhythmias in Inherited Primary Arrhythmia Syndromes
The inherited primary arrhythmia syndromes (IPAS) are a heterogeneous group of diseases caused by mutations in genes encoding for cardiac ion channels. People affected by one of these inherited diseases have no overt structural cardiac abnormalities but are at higher risk of sudden cardiac death due to the occurrence of…
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Author(s):
Greg Mellor
,
Elijah R Behr
Added:
3 years ago
Sudden unexplained death syndrome (SUDS)1 is rare in the young but when it occurs it is devastating for family and friends, and affects whole communities. That it can affect fit, athletic individuals and may be related to competitive sports only adds to the sense of incomprehension and injustice felt by wider society. In comparison with the older population, where sudden death is more common and…
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