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Author(s): Caroline H Roney , Andrew L Wit , Nicholas S Peters Added: 3 years ago
Determining optimal treatment strategies for complex arrhythmogenesis in AF is confounded by the lack of consensus on the mechanisms causing AF. Fundamental to defining arrhythmogenic mechanisms of AF are the distinctions and interplay between functional features (determined by the electrophysiology of a cell) and structural features (determined by whether a structural or anatomical feature is… View more
Author(s): Seigo Yamashita , Ashok J Shah , Saagar Mahida , et al Added: 3 years ago
Catheter ablation therapy has been widely used for rhythm control in patients with atrial fibrillation(AF).1 Since the first report in 1994,2 several interventional techniques have been proposed for AF, including replication of the surgical Maze,2 targeting pulmonary vein (PV) foci,3 segmental ostial and circumferential PV isolation,4,5 ganglionated plexi ablation,6 linear lesions in the left… View more
Author(s): Manav Sohal , Rajin Choudhury , Philippe Taghji , et al Added: 3 years ago
Ablative therapies for atrial fibrillation have gained popularity worldwide and prompted the development of new, and often complex, tools to achieve higher levels of success. Pulmonary vein (PV) isolation is widely considered as the cornerstone of successful catheter ablation based on seminal work by Haissaguerre et al.1 Successful isolation of the PVs is now the most commonly sought endpoint in… View more
Author(s): Amir A Schricker , Junaid Zaman , Sanjiv M Narayan Added: 3 years ago
Catheter ablation is more effective than pharmacological therapy for the secondary prevention of patients with paroxysmal1,2 and persistent3,4 atrial fibrillation (AF) and has an emerging role in the primary prevention of paroxysmal AF.5,6 Nevertheless, in randomised clinical trials (RCTs) its success in treating patients with paroxysmal AF is 40–60% for a single procedure and 70% for multiple… View more
Author(s): Ashok J Shah , Meleze Hocini , Patrizio Pascale , et al Added: 3 years ago
The structural and/or functional abnormality of the cardiac electrovascular system is the most common cause of world mortality accounting for 29.0 % of deaths, followed by infectious diseases (16.2 %) and cancers (12.6 %) (WHO 2008 report). 1 Abnormalities in the cardiac electrical system (arrhythmias and sudden death) and/or mechanical function (heart failure) constitute one of the major causes… View more
Author(s): Ian Mann , Belinda Sandler , Nick WF Linton , et al Added: 3 years ago
The discovery of focal ectopy in the pulmonary veins (PVs) initiating AF1 has resulted in electrical isolation of the PVs forming the mainstay of current treatment strategies. Success rates from PV isolation (PVI) for patients with paroxysmal AF (PAF) are approximately 70–75%. However, PVI is significantly less effective for those with persistent AF, in whom many studies quote single-procedure… View more