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Author(s):
Mohamed Abbas
,
Chris Miles
,
Elijah R Behr
Added:
1 year ago
Author(s):
Josef Kautzner
,
Petr Peichl
Added:
3 years ago
Ventricular fibrillation (VF) is a complex arrhythmia that leads invariably to cardiac arrest. Its mechanisms remain largely unclear. Similar to atrial fibrillation, the mother rotor hypothesis is one plausible alternative.1,2 In larger animals, some authors reported that the dominant frequency of VF could be recorded at a junction of the left ventricular posterior wall and the septum.3-6 Others…
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Author(s):
Krystien VV Lieve
,
Arthur A Wilde
,
Christian van der Werf
Added:
3 years ago
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare but severe genetic cardiac arrhythmia disorder. Clinically, CPVT most often presents in childhood with symptoms such as syncope or sudden cardiac death due to polymorphic ventricular tachycardia (VT) or ventricular fibrillation typically triggered by exercise or emotions in the absence of structural heart disease.1
Mutations…
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Petr Peichl
Research Area(s) / Expertise:
Job title: Cardiology Fellow at the Department of Cardiology
Author
Author(s):
Giulio Conte
,
Ulrich Schotten
,
Angelo Auricchio
Added:
3 years ago
The Risk of Atrial Arrhythmias in Inherited Primary Arrhythmia Syndromes
The inherited primary arrhythmia syndromes (IPAS) are a heterogeneous group of diseases caused by mutations in genes encoding for cardiac ion channels. People affected by one of these inherited diseases have no overt structural cardiac abnormalities but are at higher risk of sudden cardiac death due to the occurrence of…
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Author(s):
Neil T Srinivasan
,
Richard Schilling
Added:
3 years ago
An estimated 180,000–300,000 sudden cardiac deaths (SCD) occur in the US annually.1,2 Worldwide, sudden and unexpected cardiac death is the most common cause of death,2 accounting for 17 million deaths every year with SCD accounting for 25% of these. The accepted definition of SCD is death that occurs within one hour of onset of symptoms in witnessed cases, and within 24 hours of last being seen…
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Author(s):
A John Camm
,
Bernard J Gersh
,
Demosthenes G Katritsis
Added:
3 years ago
Inherited arrhythmias comprise a group of disorders with inherited susceptibility to arrhythmias and conduction disturbances due to mutations in genes mainly encoding the Na+, and K+ channels, and other arrhythmogenic mechanisms such as those linked to Ca++ transport (Table 1).1 The majority of heritable cardiomyopathies and channelopathies are associated with disease-susceptibility genes…
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Author(s):
Carlo Pappone
,
Vincenzo Santinelli
Added:
3 years ago
Historical Precedents
Brugada syndrome (BrS) was first described more than 25 years ago as a clinical entity in people resuscitated from sudden cardiac death due to documented VF.1 The original 1992 case series described eight patients without apparent structural heart disease who all had VF associated with persistent coved ST-segment elevation in the right precordial leads.1 In 1996 this…
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Author(s):
Gonca Suna
,
Greg J Mellor
Added:
4 months ago
Author(s):
Greg Mellor
,
Elijah R Behr
Added:
3 years ago
Sudden unexplained death syndrome (SUDS)1 is rare in the young but when it occurs it is devastating for family and friends, and affects whole communities. That it can affect fit, athletic individuals and may be related to competitive sports only adds to the sense of incomprehension and injustice felt by wider society. In comparison with the older population, where sudden death is more common and…
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