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3 years ago
Atrial fibrillation (AF) is the most commonly encountered arrhythmia in clinical practice. The discovery that pulmonary veins (PV) play a prominent role in the pathogenesis of AF has revolutionised the management of AF. PV isolation has become the most widely used technique for treatment of paroxysmal AF. Since the initial discovery implicating PVs in AF pathogenesis, the mechanistic link between…
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3 years ago
Pulmonary vein isolation (PVI) has become an accepted therapeutic strategy for AF.1 The cryoballoon (CB) ablation system has been introduced into clinical practice as a tool for a single-shot anatomical based-PVI, and a comparable efficacy of the CB ablation to radiofrequency (RF) ablation has been demonstrated in a prospective randomised study.2–4
The recently introduced second-generation CB …
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3 years ago
The pathophysiology of AF is complex and incompletely understood to date.1,2 AF is a progressive disease of the atria involving a multitude of mechanisms related to its initiation, maintenance and progression. Experimental evidence suggest that AF is characterised by alternations in atrial size, shape electrophysiology, autonomic innervation, and cardiomyocyte metabolism, as well as development…
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3 years ago
Determining optimal treatment strategies for complex arrhythmogenesis in AF is confounded by the lack of consensus on the mechanisms causing AF. Fundamental to defining arrhythmogenic mechanisms of AF are the distinctions and interplay between functional features (determined by the electrophysiology of a cell) and structural features (determined by whether a structural or anatomical feature is…
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1 year ago
EHRA 2023 — Dr Vivek Y Reddy (Mount Sinai Hospital, US) shares the details of a study looking at conformable PVI catheters for pulmonary vein isolation (PVI). The study investigates the use of a highly deformable mesh-like eight-french catheter that has recently received CE mark approval. The trial is ongoing at three centers.
Questions:
What's the research context or rationale?
Describe the…
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3 years ago
AF is the most common sustained arrhythmia, and carries an increased risk of cardiovascular and cerebrovascular complications. The latest estimates on the prevalence of AF portray an alarming scenario, with a steep increase in the number of people developing AF and prediction that the number affected will more than double in the next 40 years.1 Among the strategies to restore and maintain sinus…
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3 years ago
The most common sustained cardiac arrhythmia is AF, which is associated with increased risk of stroke and heart failure, and represents a significant global health burden.1 Pulmonary vein isolation (PVI) is the standard treatment for symptomatic, drug resistant paroxysmal and persistent AF.2 Radiofrequency (RF) ablation, the most widely used ablation technique, aims to achieve circumferential…
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1 year ago
In this short video from Arrhythmia Academy's Journal Club, Prof Roland Tilz (University Heart Centre Lübeck, Lübeck, DE) and Prof Josef Kautzner (Institute for Clinical and Experimental Medicine, Prague, CZ) sit down to discuss the use of short-duration-ablation for pulmonary vein isolation (PVI). Prof Tilz provides a 10-minute presentation overview of VHPSD ablation technologies, including…
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6 years ago
Added:
3 years ago
Catheter ablation of AF has become an established therapy and may have the potential to cure this most commonly encountered sustained arrhythmia. Previous studies have demonstrated that pulmonary veins (PVs) are a major source of the ectopic beats that initiate AF. PV isolation in patients with symptomatic paroxysmal AF refractory to antiarrhythmic drugs is effective; however, it is difficult to…
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