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Author(s): Jonathan S Steinberg , David Slotwiner Added: 3 years ago
Electrical Remodelling Evidence Supporting Atrial Remodelling The concept of electrical remodelling was first introduced in 1995 simultaneously by Wijffels et al.1 and Morillo et al.2 who demonstrated that once sustained atrial fibrillation (AF) was induced in goats, or rapid atrial pacing was performed in dogs, physiological changes occurred that favoured the maintenance of AF.3 This led to the… View more

Electrophysiology & Arrhythmia
AHA 21 SMART-CRT: Effects of AV Optimization on CRT Outcomes
Author(s): Michael R Gold Added: 2 years ago
In this video, Dr Michael R Gold (Medical University of South Carolina, Charleston, SC, US) shares the primary results of the Smart-CRT Trial. The study investigated the efficacy of an atrioventricular optimization algorithm to improve reverse remodeling among patients undergoing cardiac resynchronization therapy (CRT) in the presence of interventricular electrical delay. Discussion Points… View more

Electrophysiology & Arrhythmia
Author(s): Jens Kienemund , Karl-Heinz Kuck , Christian Frerker Added: 3 years ago
Prevalence of Functional Mitral Regurgitation in Patients with Chronic Heart Failure Secondary or functional mitral regurgitation (FMR) is a common problem in patients with chronic heart failure (HF) due to dilated cardiomyopathy, regardless of aetiology.1 FMR results from an imbalance between the closing and the tethering forces that act on the mitral valve leaflets.2,3 A chart review of… View more

Heart Failure

Electrophysiology & Arrhythmia
Author(s): Antonio Sorgente , Riccardo Cappato Added: 3 years ago
Cardiac resynchronisation therapy (CRT) is a well-established non-pharmacological treatment option for patients with refractory symptomatic heart failure (HF) already under optimal medical therapy.1 CRT is founded on the principle that interventricular conduction disturbances and especially left bundle branch block (LBBB) are deleterious to cardiac performance and may contribute to the systolic… View more

Heart Failure

Electrophysiology & Arrhythmia
Author(s): Khang-Li Looi , Anthony SL Tang , Sharad Agarwal Added: 3 years ago
Heart failure (HF) is a growing and major health burden in western countries. The prevalence of HF is estimated at 1–2 % in the western world, and the incidence approaches 5–10 per 1,000 persons per year.1Cardiac resynchronisation therapy (CRT) has been shown in multiplestudies to improve HF symptoms, quality of life and improve survivals.2–6The two landmark studies, Comparison of Medical Therapy… View more

Heart Failure

Electrophysiology & Arrhythmia
NOACs: Monitoring their Anticoagulant Effects and Use of Antidotes
Author(s): Nur A Rahmat , Gregory YH Lip Added: 3 years ago
Until recently, the vitamin K antagonist (VKA, e.g. warfarin) class of drugs was the only oral anticoagulant in use. VKAs have important inter- and intra-patient variability, influenced by diet, alcohol and drugs; thus, regular anticoagulation monitoring is necessary. Indeed, VKAs offer their best efficacy and safety when the average time in therapeutic range (TTR) is >65–70 % in a particular… View more

Electrophysiology & Arrhythmia
Author(s): Geoffrey F Lewis , Michael R Gold Added: 3 years ago
Since the introduction of CRT more than 20 years ago, its role in mild to severe systolic heart failure has become well established. CRT has been shown to decrease mortality, reduce heart failure hospitalisations and improve functional status in patients with NYHA class II–IV heart failure and QRS prolongation, most commonly with LBBB pattern.1 One of the major limitations of CRT implementation… View more

Heart Failure

Electrophysiology & Arrhythmia
Obesity and AF
Author(s): Ahmed M Al-Kaisey , Jonathan M Kalman Added: 2 years ago

Electrophysiology & Arrhythmia

Prevention & Chronic Conditions
Miracor Medical Systems
Miracor Medical Systems GmbH is an Austrian medical device company developing disruptive solutions to treat severe heart diseases; striving to bring back cardiac patients to normal life. Miracor develops and commercializes the PiCSO (Pressure-controlled Intermittent Coronary Sinus Occlusion) Impulse System,a technology platform designed toimprove clinical outcome of patients with impaired… View more
Atrial Fibrillation Structural Substrates: Aetiology, Identification and Implications
Author(s): Ahmed M Al-Kaisey , Ramanathan Parameswaran , Jonathan M Kalman Added: 3 years ago
AF is the most common sustained cardiac rhythm disorder and is associated with increased morbidity and mortality. Since the first description of AF initiation by triggers from pulmonary veins sleeves, pulmonary vein isolation (PVI) has become the standard ablation strategy in patients with AF.1 However, freedom from the arrhythmia, particularly in non-paroxysmal AF, remains suboptimal, and it is… View more

Electrophysiology & Arrhythmia