Search results
Added:
3 years ago
Heart failure (HF) and AF share common pathophysiologic pathways and often coexist.1 Indeed, HF has been identified as the strongest predictor of AF in a Framingham Heart study population-based cohort.2 Moreover, HF and AF are involved in a vicious pathophysiological interplay. HF promotes AF mainly through raised atrial filling pressures, abnormal calcium handling, neurohormonal activation and…
View more
Piotr Ponikowski
Job title: Head of the Department of Heart Diseases
Author
Added:
3 years ago
Despite the fact that more than 20 years have passed since the clinical introduction of cardiac resynchronisation therapy (CRT), one of the key questions – do we need an ICD for primary prevention of sudden cardiac death (SCD) in CRT patients? – is still unanswered.
Prospective Randomised Controlled Trials
Multiple prospective randomised controlled trials have been conducted to establish the…
View more
Added:
3 years ago
The number of cardiac implantable electronic devices (CIED) has been increasing year-on-year.1 This, coupled with improvements in life expectancy,2 means that more elderly patients will meet the criteria for a CIED. National and international guidelines set out clear criteria and make recommendations for CIED use based on available evidence.3–6 However, the majority of clinical trials include few…
View more
Added:
3 years ago
Atrial fibrillation (AF) and heart failure (HF) are global epidemics that began more than a century ago, and their association with an ageing general population has brought about an increase in cardiovascular morbidity and rising healthcare costs.1,2 More than 50 % of patients with permanent AF have a concurrent diagnosis of HF and this proportion is expected to rise.3 It is well established that…
View more
Added:
3 years ago
Balanced Evaluation of the ICD
Although better known for his transformative contributions to arrhythmia mechanisms, mapping and ablation, Dr Josephson participated in investigational studies of the first implantable defibrillator2,3 and served as a principal investigator for the MUSTT (Multicenter Unsustained Tachycardia Trial) foundational trial of primary-prevention ICD therapy.4 In one of the…
View more
Added:
3 years ago
The concept of post-extrasystolic potentiation (PESP), which describes the phenomenon of increased contractility of the beat following an extrasystole, has intrigued physiologists and clinicians for more than 120 years. Since its first description in 1885 by Oskar Langendorff,1 PESP has become a widely debated concept, not only for its fundamental basis but also because of the potential…
View more
Added:
3 years ago
An estimated 180,000–300,000 sudden cardiac deaths (SCD) occur in the US annually.1,2 Worldwide, sudden and unexpected cardiac death is the most common cause of death,2 accounting for 17 million deaths every year with SCD accounting for 25% of these. The accepted definition of SCD is death that occurs within one hour of onset of symptoms in witnessed cases, and within 24 hours of last being seen…
View more
Added:
3 years ago
Ventricular arrhythmias (VA) are commonly associated with structural heart disease and have substantial impact on patient outcomes and health system costs. Within the realm of cardiomyopathy (CM), there has been substantial progress with respect to ischaemic CM (ICM) in the understanding of infarct related scar biology and scar-mediated ventricular tachycardia (VT).
This has led to interventions…
View more
Added:
3 years ago
Ventricular arrhythmias are a therapeutic challenge. They occur frequently in clinical practice, are found in patients with and without structural heart disease, and most importantly, are unpredictable and potentially deadly. Patients with a history of sustained ventricular tachycardia (VT) and VF or those at high risk for such arrhythmias, may require an ICD to prevent sudden cardiac arrest…
View more
