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Author(s): David J Sprenkeler , Marc A Vos Added: 3 years ago
The concept of post-extrasystolic potentiation (PESP), which describes the phenomenon of increased contractility of the beat following an extrasystole, has intrigued physiologists and clinicians for more than 120 years. Since its first description in 1885 by Oskar Langendorff,1 PESP has become a widely debated concept, not only for its fundamental basis but also because of the potential… View more
Author(s): Jason G Andrade , Atul Verma , Laurent Macle , et al Added: 3 years ago
AF is a common chronic, progressive disease, characterised by exacerbations and remissions. Over the past 10–15 years, multiple large-scale observational studies and randomised controlled trials have demonstrated that catheter ablation is superior to anti-arrhythmic drug (AAD) therapy in maintaining sinus rhythm and improving AF-related symptoms, exercise capacity and quality of life.1–7 The… View more
Author(s): Henry Chubb , Mark O’Neill , Eric Rosenthal Added: 3 years ago
Device therapy is increasingly employed in the management of complex congenital heart disease (CHD). Bradycardias, most often related to sinus nodal dysfunction (SND) or atrioventricular nodal (AVN) block, may necessitate the implantation of pacing devices, while malignant arrhythmias may be treated by appropriate use of implantable cardioverter defibrillators (ICDs). However, there is a complex… View more
Author(s): Cristina E Molina , Jordi Heijman , Dobromir Dobrev Added: 3 years ago
Optimal cardiac function depends on appropriate rate and force of contraction, with specific cardiac regions having developed particular beat-to-beat properties depending on their individual functions. For example, isovolumetric contraction time is shorter in the right ventricle (RV) than in the left ventricle (LV). At the cellular level, cardiac function is regulated by regional cardiomyocyte… View more
Author(s): Konstantinos D Rizas , Wolfgang Hamm , Stefan Kääb , et al Added: 3 years ago
Experimental and clinical studies have demonstrated that enhanced sympathetic autonomic nervous system (SANS) activity can destabilise myocardial repolarisation,1–4 increasing vulnerability to developing fatal cardiac arrhythmias.5–8 Accordingly, assessment of SANS activity has always been a major goal for cardiac risk stratification methods. Various non-invasive methods including assessment of… View more
Author(s): Theodoros Christophides , Sarosh Khan , Mahmood Ahmad , et al Added: 3 years ago
Lightning strikes between clouds and ground objects occur when the difference in electrical potential between the two is greater than 30,000 Volts, as thus they are able to exceed the atmospheric electrical resistance, generating currents that vary from 30,000 to 100,000 Amperes, and lasting between 0.1–0.001 seconds. As per data from the Lightning Imaging Sensor (LIS)-equipped satellite… View more
Author(s): Philippe Charron , Eloisa Arbustini , Gisèle Bonne Added: 3 years ago
Most mutations of the LMNA gene affect the heart, causing a dilated cardiomyopathy, ususally with conduction defect and ventricular arrhythmia, with or without skeletal muscle involvement. Although a relatively rare disease, cardiologists should be aware of laminopathies (diseases caused by LMNA gene mutations) because of the particularly aggressive course compared with most other… View more