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Author(s): Zhao Liu , J Kevin Donahue Added: 3 years ago
In the United States, atrial fibrillation (AF) is the most common sustained cardiac arrhythmia affecting approximately six million patients and contributing to a greatly increased risk of stroke, heart failure (HF) and overall morbidity and mortality.1,2 The prevalence of AF is increasing as the average age of the population increases.3,4 Currently available therapies for AF are suboptimal… View more

Electrophysiology & Arrhythmia

Prevention & Chronic Conditions
Author(s): Simon Ermakov , Melvin Scheinman Added: 3 years ago
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiomyopathy characterised by progressive replacement of the ventricular myocardium by fibrofatty tissue.1 Patients with the disease are predisposed to ventricular arrhythmias, heart failure and sudden cardiac death. Pathophysiology ARVC has a strong genetic basis with most disease variants displaying an autosomal dominant… View more

Standards & Guidelines

Heart Failure
Reentrant Arrhythmias of the His-Purkinje System
Author(s): Raphael K Sung , Penelope A Boyden , Satoshi Higuchi , et al Added: 2 years ago

Electrophysiology & Arrhythmia
Atrial Tachycardias After Atrial Fibrillation Ablation: How to Manage?
Author(s): Yuan Hung , Shih-Lin Chang , Wei-Shiang Lin , et al Added: 3 years ago
AF is the most common clinical arrhythmia that causes severe adverse cardiovascular events, such as ischaemic stroke and acute heart failure.1 Triggers from the pulmonary vein (PV) have been identified as crucial ectopic sources that initiate AF and pulmonary vein isolation (PVI) is the cornerstone for catheter ablation of AF.2,3 Per the European and US AF guidelines, catheter ablation of AF is… View more

Electrophysiology & Arrhythmia
Author(s): Steven M Markowitz , George Thomas , Christopher F Liu , et al Added: 3 years ago
Pioneering electrophysiology studies in the 1990s defined the anatomical boundaries of typical atrial flutter, identified regions for effective catheter ablation of this arrhythmia and described procedural endpoints to minimise recurrences after ablation. Activation and entrainment mapping demonstrated that typical flutter arises from reentry around the tricuspid annulus.1 Criteria to confirm… View more

Electrophysiology & Arrhythmia
Author(s): Nabil El-Sherif , Gioia Turitto , Mohamed Boutjdir Added: 3 years ago
Since its initial description by Jervell and Lange-Nielsen in 1957,1 congenital long QT syndrome (LQTS) has been the most investigated cardiac ion channelopathy. A prolonged QT interval on the surface ECG is a surrogate measure of prolonged ventricular action potential duration (APD). Congenital as well as acquired alterations in certain cardiac ion channels can affect their currents in such a… View more

Electrophysiology & Arrhythmia
Drug-induced AF: Arrhythmogenic Mechanisms and Management Strategies
Author(s): Bingxun Li , Mingjie Lin , Lin Wu Added: 2 weeks ago

Electrophysiology & Arrhythmia
Idiopathic Outflow Tract Ventricular Arrhythmia Ablation
Author(s): Jackson J Liang , Yasuhiro Shirai , Aung Lin , et al Added: 3 years ago
Idiopathic ventricular arrhythmias (VAs) are comprised of ventricular premature depolarisations, non-sustained ventricular tachycardia (VT)and rarely sustained VT, and these typically occur in the absence of structural heart disease. In general, idiopathic VAs tend to have a benign prognosis, although a high burden of VAs can result in left ventricular (LV) systolic dysfunction and cardiomyopathy… View more

Electrophysiology & Arrhythmia
Author(s): Sebastian Clauss , Moritz F Sinner , Stefan Kääb , et al Added: 3 years ago
Atrial fibrillation (AF) is the most common arrhythmia experienced in clinical practice, and is responsible for significant morbidity and mortality.1 It affects more than 6 million people in Europe.1 The lifetime risk of developing AF after the age of 40 is approximately 25 %.1 AF is a major public health burden as it is associated with an increased risk of stroke by fivefold, dementia by twofold… View more

Electrophysiology & Arrhythmia

Prevention & Chronic Conditions
AER Sicouri
Author(s): Serge Sicouri , Charles Antzelevitch Added: 3 years ago
The link between sudden unexplained death in individuals with mental health problems who are administered antipsychotic drugs has been recognised for over a century.1 A clear relationship has emerged over the past 25 years between antipsychotic drugs, prolongation of the QT interval of the ECG, atypical polymorphic tachycardia known as torsade de pointes (TdP) and sudden cardiac death (SCD). A… View more

Electrophysiology & Arrhythmia