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Author(s):
José-Ángel Cabrera
,
Robert H Anderson
,
Andreu Porta-Sánchez
,
et al
Added:
2 years ago
Author(s):
Sharon A George
,
N Rokhaya Faye
,
Alejandro Murillo-Berlioz
,
et al
Added:
3 years ago
More than 100years have passed since the atrioventricular node (AVN) was first discovered by Sunao Tawara1 and described as a “Knoten” of tissue located at the proximal end of the Bundle of His (BoH).2 Despite the numerous advances in knowledge regarding the structure and function of the AVN, there are still several controversies that need to be addressed in both clinical and scientific settings…
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Author(s):
Nisha Gilotra
,
David Okada
,
Apurva Sharma
,
et al
Added:
3 years ago
Sarcoidosis is an inflammatory granulomatous disease that can affect any organ. Systemic sarcoidosis is known to affect young adults, with a second peak in women >50 years of age, as demonstrated in Scandinavian and Japanese studies.1–4 In the US, the lifetime risk of sarcoidosis is 2.4% for black people and 0.85% for white people.1 The incidence of cardiac involvement has been increasingly…
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Mimics of Hypertrophic Cardiomyopathy - Diagnostic Clues to Aid Early Identification of Phenocopies
Author(s):
Rajiv Sankaranarayanan
,
Eleanor J Fleming
,
Clifford J Garratt
Added:
3 years ago
Article
Author(s):
Penelope A Boyden
,
Wen Dun
,
Bruno D Stuyvers
Added:
3 years ago
Abnormalities in electrical rhythm were studied by Einthoven at the start of the 20th century. In the 1940s, studies by Bozler et al.1 described contractile signals that appeared to be ‘triggered’ heart beats. Today we use the term delayed afterdepolarisations (DADs) to refer to oscillations in voltage that follow a driven action potential.
In the mid-1970s, progress was made when Lederer and…
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Author(s):
Demosthenes G Katritsis
,
Mark E Josephson
Added:
3 years ago
Atrioventricular nodal reentrant tachycardia (AVNRT) denotes re-entry in the area of the AV node, and represents the most common regular arrhythmia in the human.1 Although several models have been proposed to explain the mechanism of the arrhythmia in the context of the complex anatomy and the anisotropic properties of the atrioventricular (AV) node and its atrial extensions (see Figure 1),2 the…
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Cardiac Pacing in Reflex Syncope
Author(s):
Marco Tomaino
,
Vincenzo Russo
,
Daniele Giacopelli
,
et al
Added:
2 years ago
Article
Author(s):
David Hamon
,
Jane Taleski
,
Marmar Vaseghi
,
et al
Added:
3 years ago
Orthotopic heart transplantation (OHT) is the most effective long-term therapy for end-stage heart disease, with implanted left ventricular assist devices (‘destination therapy’) as an alternative for selected patients. The denervation of the transplanted heart with complete loss of autonomic nervous system modulation, the use of immunosuppressant drugs, as well as the risk of allograft rejection…
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Author(s):
Brett Wanamaker
,
Thomas Cascino
,
Vallerie V McLaughlin
,
et al
Added:
3 years ago
Pulmonary hypertension (PH) is a chronic condition that is characterised by elevated pulmonary vascular pressures and can be caused by several disease processes (see Table 1).1 Regardless of the aetiology, PH is a progressive disease with a clinical course characterised by frequent decompensations in advanced stages and often a poor prognosis despite the development of novel therapeutic agents.2…
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Author(s):
Dario DiFrancesco
Added:
3 years ago
HCN4 (hyperpolarisation-activated, cyclic nucleotide gated 4) channels, the pore-forming α–subunits of ‘funny’ channels originally described in pacemaker cells of the sinoatrial node (SAN),1 are responsible for the early phase of diastolic depolarisation in these cells and are key determinants of pacemaker generation and control of heart rate.2–5 HCN4 channels are selectively expressed in the SAN…
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