Unmissable EP Papers

Received date
12 March 2018
Accepted date
12 March 2018
Arrhythmia & Electrophysiology Review 2018;7(1):07

The most important papers on arrhythmias and electrophysiology published in 2017, selected by the editors of Arrhythmia and Electrophysiology Review (AER).


  1. Ortiz M, Martín A, Arribas F, et al. Randomized comparison of intravenous procainamide vs. intravenous amiodarone for the acute treatment of tolerated wide QRS tachycardia: the PROCAMIO study. Eur Heart J 2017;38:1329–35. DOI: 10.1093/ eurheartj/ehw230; PMID: 27354046.
  2. Khan SU, Winnicka L, Saleem MA, et al. Amiodarone, lidocaine, magnesium or placebo in shock refractory ventricular arrhythmia: a Bayesian network meta-analysis. Heart Lung 2017;46:417–24. DOI: 10.1016/j.hrtlng.2017.09.001; PMID:28958592.
  3. Mazzanti A, Maragna R, Vacanti G, et al. Hydroquinidine prevents life-threatening arrhythmic events in patients with short QT syndrome. J Am Coll Cardiol 2017;70:3010–5. DOI: 10.1016/j.jacc.2017.10.025; PMID: 29241489.
  4. Boersma L, Barr C, Knops R, et al.; EFFORTLESS Investigator Group. Implant and midterm outcomes of the Subcutaneous Implantable Cardioverter-Defibrillator Registry: the EFFORTLESS study. J Am Coll Cardiol 2017;70:830–41. DOI: 10.1016/j. jacc.2017.06.040; PMID: 28797351.
  5. Leyva F, Zegard A, Acquaye E, et al. Outcomes of cardiac resynchronization therapy with or without defibrillation in patients with nonischemic cardiomyopathy. J Am Coll Cardiol 2017;70:1216–27. DOI: 10.1016/j.jacc.2017.07.712; PMID: 28859784.
  6. Al-Khatib SM, Gillis AM, Curtis AB. Centers for Medicare and Medicaid Services' decision to reconsider coverage indications for ICDs: where to now? Circulation 2018;137:317–9. DOI: 10.1161/CIRCULATIONAHA.117.031786; PMID: 29070501.
  7. Bongiorni MG, Kennergren C, Butter C, et al.; ELECTRa Investigators. The European Lead Extraction ConTRolled (ELECTRa) study: a European Heart Rhythm Association (EHRA) registry of transvenous lead extraction outcomes. Eur Heart J 2017;38:2995–3005. PMID: 28369414.
  8. Calkins H, Willems S, Gerstenfeld EP, et al.; RE-CIRCUIT Investigators. Uninterrupted dabigatran versus warfarin for ablation in atrial fibrillation. N Engl J Med 2017;376:1627–36. DOI: 10.1056/NEJMoa1701005; PMID: 28317415.
  9. Kapel GF, Sacher F, Dekkers OM, et al. Arrhythmogenic anatomical isthmuses identified by electroanatomical mapping are the substrate for ventricular tachycardia in repaired Tetralogy of Fallot. Eur Heart J 2017;38:268–76.; PMID: 28182233.
  10. Pappone C, Brugada J, Vicedomini G, et al. Electrical substrate elimination in 135 consecutive patients with Brugada syndrome. Circ Arrhythm Electrophysiol 2017;10:e005053. DOI: 10.1161/CIRCEP.117.005053; PMID: 28500178.


  1. Cuculich PS, Schill MR, Kashani R, et al. Noninvasive cardiac radiation for ablation of ventricular tachycardia. N Engl J Med 2017;377:2325–36. DOI: 10.1056/NEJMoa1613773; PMID: 29236642.
  2. Reddy VY, Miller MA, Neuzil P, et al. Cardiac resynchronization therapy with wireless left ventricular endocardial pacing: the SELECT-LV study. J Am Coll Cardiol 2017;69:2119–29. DOI: 10.1016/j.jacc.2017.02.059; PMID: 28449772.
  3. Trayanova NA, Pashakhanloo F, Wu KC, Halperin HR. Imaging-based simulations for predicting sudden death and guiding ventricular tachycardia ablation. Circ Arrhythm Electrophysiol 2017;10:e004743. DOI: 10.1161/CIRCEP.117.004743; PMID: 28696219.
  4. Baruscotti M, Bucchi A, Milanesi R, et al. A gain-of-function mutation in the cardiac pacemaker HCN4 channel increasing cAMP sensitivity is associated with familial inappropriate sinus tachycardia. Eur Heart J 2017;38:280–8. DOI: 10.1093/ eurheartj/ehv582; PMID: 28182231.
  5. Chu M, Novak SM, Cover C, et al. Increased cardiac arrhythmogenesis associated with gap junction remodeling with upregulation of RNA-binding protein FXR1. Circulation 2018;137:605–18. DOI: 10.1161/CIRCULATIONAHA.117.028976; PMID: 29101288.

Demosthenes Katritsis, Editor-in-Chief, AER, Hygeia Hospital, Athens, Greece
Andrew Grace, Section Editor – Arrhythmia Mechanisms/ Basic Science, AER, University of Cambridge, UK
Angelo Auricchio, Section Editor – Implantable Devices, AER, Fondazione Cardiocentro Ticino, Lugano, Switzerland
Karl-Heinz Kuck, Section Editor – Clinical Electrophysiology and Ablation, AER, Asklepios Klinik St Georg, Hamburg, Germany